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Rapaport , M. H., Nierenberg , A. A., Howland , R, Dording , C, Schettler , P. J., & Mischoulon , D. (2011). The treatment of minor depression with St John’s Wort or Citalopram : Failure to show benefit over placebo. Journal of Psychiatric Research, 45 (7), 931-941. https:// doi.org/ 10.1016/j.jpsychires.2011.05.001
This article evaluates the effectiveness of St John’s Wort, Citalopram and placebo in decreasing the severity of symptoms for subjects with minor depression. In this study, a 12-week double-blind randomised method was adopted with participants recruited through clinical referrals and community advertising. Seventy-three subjects were assigned into three treatment groups and received daily the following dosage: 810 mg of St John’s Wort, 20 mg of Citalopram and a look-alike placebo. A total of six visits data was collected over the study period using validated and structured assessments and personal interviews. The findings show similar adverse reactions; however, Citalopram scored the highest at 100 percent with St John's wort scoring 84.6 percent and placebo 91.3 percent. Although the research supports the use of St John’s Wort in managing depression there is no certainty as to which treatment would be better for minor depression. The limitations found in this study including the small sample size of 73 subjects and exclusion of subjects with “organic mental disorders, substance use disorders, current or within one year of psychotic symptoms or disorders, bipolar disorder or antisocial personality disorder”(p.3) call for further research. This article is relevant to my research as it highlights the non-pharmacological treatment for minor depression.
